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Abnormal hippocampo-cortical theta-gamma phase-amplitude coupling in Alzheimer's disease
2026-02-09
psychiatry and clinical psychology
Title + abstract only
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INTRODUCTIONCognitive decline in Alzheimers disease (AD) may arise not only from neuronal loss but also from disrupted temporal coordination across distributed networks. Prior works in healthy individuals has shown memory-related modulation of hippocampal-cortical phase-amplitude coupling (PAC). We hypothesized alteration of resting-state hippocampo-cortical PAC in AD which relates to cognitive impairment. METHODSResting-state magnetoencephalography (MEG) data were obtained from 78 AD patients ...
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