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Reservoir and Phylogenetic Signatures Identify Distinct Subsets of HIV-1 Nonsuppressible Viremia

2026-02-06 hiv aids Title + abstract only
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In nonsuppressible HIV viremia (NSV), individuals have persistently detectable viral load despite adherence to [≥]2 fully active antiretroviral drugs. NSV represents an area of clinical uncertainty and an opportunity to understand the mechanisms of HIV persistence. We performed in-depth virologic characterization to identify distinct NSV phenotypes. We categorized participants into those who had persistent viremia after antiretroviral therapy (ART) initiation (primary NSV) and those who had N...

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