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Functional MRS uncovers age-related alterations in cerebral lactate dynamics during emotional-cognitive engagement, revealing metabolic vulnerability in the dACC

2026-02-06 psychiatry and clinical psychology Title + abstract only
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IntroductionLactate plays dual roles in neuronal energy metabolism and signalling. The dorsal anterior cingulate cortex (dACC), a region with high baseline glycolytic activity implicated in psychiatric disorders, may exhibit dynamic lactate responses to graded cognitive-emotional demands. Because mitochondrial function declines with age, aging may model whether fMRS-derived lactate dynamics can detect latent neurometabolic vulnerabilities. MethodsUsing fMRS, we monitored dACC metabolite changes...

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