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Spatial mapping of Ethiopian cutaneous leishmaniasis lesions reveals distinct tissue level immune programs
2026-02-05
infectious diseases
Title + abstract only
View on medRxiv
Show abstract
Ethiopian cutaneous leishmaniasis (CL) shows remarkably heterogeneous clinical presentations, but the underlying immunopathological mechanisms driving this heterogeneity in disease presentation remains poorly understood. To characterise the local immune response in Ethiopian CL, we performed spatial transcriptomics on paired lesional and non-lesional skin punch biopsies from five Ethiopian CL patients. We used reference-free deconvolution, morphology-guided regional analyses, and immunohistochem...
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