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Sustained freedom from disease activity in secondary progressive multiple sclerosis by targeting invariant NKT cells: a phase 2 trial of OCH

2026-02-05 allergy and immunology Title + abstract only
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Multiple sclerosis (MS) therapies primarily rely on lymphocyte depletion or trafficking blockade, carrying risks of systemic immunosuppression; however, such treatments have limited efficacy in secondary progressive multiple sclerosis (SPMS). Thus, drugs that target stage-specific inflammation without broad immunosuppression are an unmet clinical need. In this double-blind, placebo-controlled phase II trial, 30 patients with relapsing MS received weekly oral OCH or placebo for 24 weeks. In the ...

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