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Transdiagnostic Neurobehavioral Gradients and Environmental Interactions in Youth with Major Psychiatric Disorders
2026-02-05
psychiatry and clinical psychology
Title + abstract only
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Major psychiatric disorders typically emerge in youth and exhibit shared and disorder-specific behavioral phenotypes and neuroanatomical alterations, yet the transdiagnostic neurobehavioral gradients and environmental interactions contributing to this heterogeneity remain poorly understood. Here, we present a transdiagnostic cohort of 1,755 youths aged 10-24 years, including 1,040 patients with bipolar disorder (BD), major depressive disorder (MDD), or schizophrenia spectrum disorder, and 715 he...
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