Ecological context structures duplication and mobilization of antibiotic and metal resistance genes in bacteria
Tran, E.; Xu, P. N.; Assis, R.
Show abstract
Antibiotic resistance is a global challenge driven by the persistence and spread of resistance genes across ecological contexts. While mobile genetic elements (MGEs) facilitate horizontal gene transfer, gene duplication represents an additional mechanism through which resistance genes can be amplified, diversified, and maintained under selection. How these processes interact across environments remains poorly understood. Here, we examined genome-level patterns of resistance gene abundance, duplication, and mobilization across clinical, agricultural, and wastewater settings, focusing on both antibiotic resistance genes (ARGs) and metal resistance genes (MRGs). Resistance gene profiles were strongly structured by environment, with distinct duplication patterns emerging across sources. Duplicate genes were frequently associated with MGEs, although the strength of this relationship varied by resistance type and ecological context. Despite frequent co-occurrence of ARGs and MRGs, their duplication and mobilization dynamics were not uniformly coupled at the genome level. Together, these findings highlight gene duplication as a context-dependent contributor to resistance evolution and underscore the importance of ecological setting in shaping how resistance genes persist and spread across microbial communities.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Targeted sequencing of Enterobacterales bacteria using CRISPR-Cas9 enrichment and Oxford Nanopore Technologies 95%
- A Distinct Contractile Injection System Found in a Majority of Adult Human Microbiomes 94%
- Strain-level analysis of Bifidobacterium spp. from gut microbiomes of adults of differing lactase persistence genotypes 94%
Similar papers in this journal
- Evolution of plasmid mobility: origin and fate of non-conjugative plasmids 93%
- Dynamics of mutation accumulation and adaptation during three years of evolution under long-term stationary phase 93%
- A dual barcoding approach to bacterial strain nomenclature: Genomic taxonomy of Klebsiella pneumoniae strains 93%
Similar papers in this journal
- Profiling cell envelope-antibiotic interactions reveals vulnerabilities to β-lactams in a multidrug-resistant bacterium 95%
- A unique symbiosome in an anaerobic single-celled eukaryote 94%
- Genetic potential for aerobic respiration and denitrification in globally distributed respiratory endosymbionts 94%
Similar papers in this journal
- Off-target integron activity leads to rapid plasmid compensatory evolution in response to antibiotic selection pressure 95%
- Elevated rates and biased spectra of mutations in anaerobically cultured lactic acid bacteria 94%
- Parallel evolution of tobramycin resistance across species and environments 94%
Similar papers in this journal
- Transporter genes in biosynthetic gene clusters predict metabolite characteristics and siderophore activity 94%
- Contiguous and complete assemblies of Blastocystis gut microbiome-associated protists reveal evolutionary diversification to host ecology 94%
- Rates and spectra of de novo structural mutation in Chlamydomonas reinhardtii 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.