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Identification of Novel mRNA Biomarkers with Improved Performance for Colorectal Cancer Screening from a Multicenter Large Gene Screen

2026-02-07 gastroenterology Title + abstract only
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BackgroundColorectal cancer (CRC) is a leading cause of cancer mortality. While early detection improves outcomes, current non-invasive tests often lack sensitivity for early-stage CRC and advanced precancerous lesions (APL). Stool-based host messenger RNA (mRNA) biomarkers offer a promising approach, though the most clinically useful candidates remain undefined. MethodsWe screened for mRNA biomarkers by first using bioinformatic analysis of tissue RNA-seq datasets to identify candidate genes w...

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