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Distinct Spectral and Directional Thalamocortical Network Dynamics Define Focal Seizure Evolution

2026-02-04 neurology Title + abstract only
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Neuromodulation targeting thalamic nuclei is increasingly used to treat drug-resistant focal epilepsy, yet human intracranial EEG studies describing how thalamocortical interactions evolve across seizures remain limited. We aimed to define frequency-specific thalamocortical network dynamics from seizure onset to termination, compare thalamocortical and cortico-cortical network activation, and test whether thalamic EEG features can classify seizure state to inform closed-loop or adaptive thalamic...

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