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Neuron-Specific DNA Methylation Differences in the Prefrontal Cortex in Parkinson's Disease
2026-02-09
genetic and genomic medicine
Title + abstract only
View on medRxiv
Show abstract
Parkinsons disease (PD) is a progressive movement disorder that affects over ten million individuals worldwide. While the involvement of genetically-driven cellular mechanisms in PD pathogenesis is well-established, there is increasing evidence that epigenetic dysregulation also plays a key role. We profiled genome-wide DNA methylation in isolated neuronal, oligodendrocyte and other glial nuclei populations from the prefrontal cortex of 71 PD and 56 control individuals. We identified seven sign...
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