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Top-Down Proteomics in the Assessment of Kidney Donor Quality: a novel approach to increased organ utilization
2026-02-04
transplantation
Title + abstract only
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Kidney transplantation faces a critical paradox: while thousands await organs, approximately 30% of potential deceased donor kidneys are discarded for various reasons, including subjective assessments due to the lack of an objective molecular biomarker of preservation quality. Here, we applied novel "top-down" proteoform imaging mass spectrometry across living donor (LD), deceased donor (brain death or cardiac death), and discarded human kidneys to quantify proteoforms correlating with post-tran...
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