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Host genotypes interact with microbial communities to modulate gene expression in the human intestine

2026-02-06 genetic and genomic medicine Title + abstract only
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BackgroundInflammatory Bowel Disease (IBD) is characterized by chronic intestinal inflammation and is associated with both altered gut microbiome composition and host genetic risk. Both host genetic variants and the gut microbiome can affect host gene expression in the colon; however, it remains unclear whether interactions between the two (genotype x microbiome, GxM) shape intestinal gene regulation in humans and their contribution to IBD risk. MethodsWe analyzed publicly available data for 86...

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