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Nonlinear dynamic genetic regulation identifies peripheral drivers of neurodegenerative disease progression
2026-01-30
genetic and genomic medicine
Title + abstract only
View on medRxiv
Show abstract
The dynamic genetic regulation of gene expression during the progression of common neurodegenerative diseases (NDDs) remains poorly characterized, obscuring the genetic architecture of longitudinal clinical traits. Here, we present 2sGen-GPS, a two-stage genetic Granger temporal causality framework designed to integrate genetic variants, intermediate longitudinal molecular traits, and disease progression phenotypes. In the discovery stage, we utilized multivariate polynomial temporal genetic ass...
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