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Subclade K influenza A (H3N2) viruses display partial immune escape with preserved cross-neutralisation in a UK population

Dee, K.; Imrie, R. M.; Mojsiejczuk, L.; Raveendran, S.; Chen, H.; Guio Archila, G.; Aljeri, M. S.; Schultz, V.; Wang, Z.; Walsh, S. K.; Zhang, J.; Hutchinson, E.; Willett, B. J.; Robertson, D. L.; Hughes, J.; MacLean, O. A.; Grove, J.; Thomson, E. C.; Illingworth, C. J.; Murcia, P. R.

2026-01-29 infectious diseases
10.64898/2026.01.27.26344933 medRxiv
Show abstract

We examined whether the recent emergence of influenza A(H3N2) subclade K, associated with an unusually early influenza season in the Northern hemisphere, was accompanied by a reduction in human population immunity. Using virus neutralisation assays on pre-epidemic human sera collected in May 2025, we found evidence of moderate antigenic drift. Further, vaccines used in the 2024/2025 season induced cross-neutralising immunity. These findings provide timely insight for interpreting recent influenza epidemiology and informing vaccine strain selection.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.