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Large-Scale Identification of Novel Protein Biomarkers and Therapeutic Targets in Heart and Brain Disease
2026-01-28
cardiovascular medicine
Title + abstract only
View on medRxiv
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Neurological complications frequently impact morbidity, mortality, and quality of life in patients with cardiovascular disease, yet the biological mediators connecting cardiovascular and neurological disease are poorly understood. Leveraging data from 53,014 individuals with plasma proteomic profiles and 50,228 with cardiac and brain MRI from the UK Biobank, we systematically identified circulating proteins correlated with MRI imaging-derived phenotypes (IDPs) (404 proteins with cardiac IDPs; 76...
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