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Functional Genomic Analyses Reveal transfer RNA Modification Enzymes as Risk Genes for Bipolar I Disorder and Schizophrenia

2026-01-27 psychiatry and clinical psychology Title + abstract only
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Enzyme-mediated RNA modifications provide a versatile and dynamic regulatory layer that fine-tunes gene expression programs throughout brain development and in mature neural function. More than 100 RNA modification proteins (RMPs) have been identified to drive the dynamics of RNA modifications; yet how genetic variation in human RMP genes contributes to the risks of neurological disorders has not been systematically examined. Here we have curated 123 RMPs corresponding to 31 RNA modifications on...

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