Back

Disentangling Type 2 Diabetes Risk and Comorbidity Using Genomic Structural Equation Modeling

2026-01-26 genetic and genomic medicine Title + abstract only
View on medRxiv
Show abstract

Type 2 diabetes (T2D) is a genetically and clinically heterogeneous disorder influenced by metabolic, lifestyle, and cardiometabolic factors. Understanding the shared and distinct genetic architecture underlying T2D and its upstream risk traits is critical for improved risk prediction and stratified intervention. We applied genomic structural equation modeling (SEM) to genome-wide association study (GWAS) summary statistics for eight T2D-related phenotypes: gestational diabetes, hypertension, gl...

Predicted journal destinations

1
Nature Communications
483 training papers
Top 4% 16.8%
2
Diabetologia
23 training papers
Top 0.2% 11.2%
3
Nature Genetics
72 training papers
Top 1% 8.6%
4
The American Journal of Human Genetics
77 training papers
Top 3% 6.1%
5
Scientific Reports
701 training papers
Top 50% 5.7%
6
Human Molecular Genetics
28 training papers
Top 0.1% 4.8%
7
Genome Medicine
56 training papers
Top 3% 4.0%
8
Genetics in Medicine
57 training papers
Top 4% 3.7%
9
PLOS Genetics
39 training papers
Top 1% 3.7%
10
PLOS ONE
1737 training papers
Top 90% 2.7%
11
Cell Genomics
34 training papers
Top 2% 2.7%
12
Human Genetics and Genomics Advances
39 training papers
Top 4% 1.8%
13
eLife
262 training papers
Top 24% 1.8%
14
Frontiers in Genetics
32 training papers
Top 4% 1.5%
15
Proceedings of the National Academy of Sciences
100 training papers
Top 12% 1.3%
16
European Journal of Human Genetics
25 training papers
Top 4% 1.3%
17
BMC Medicine
155 training papers
Top 25% 1.1%
18
Circulation: Genomic and Precision Medicine
30 training papers
Top 6% 1.1%
19
Translational Psychiatry
94 training papers
Top 9% 0.9%
20
Bioinformatics
24 training papers
Top 3% 0.9%
21
Nature
58 training papers
Top 8% 0.9%
22
Communications Biology
36 training papers
Top 4% 0.9%
23
Brain
69 training papers
Top 11% 0.7%
24
npj Genomic Medicine
18 training papers
Top 6% 0.7%
25
Genes
21 training papers
Top 6% 0.7%
26
Journal of Medical Genetics
22 training papers
Top 5% 0.7%
27
PLOS Medicine
95 training papers
Top 25% 0.7%
28
Nature Medicine
88 training papers
Top 21% 0.7%