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Pharmacogenomic architecture of antihypertensive switching implicates neurotensin-NTSR1 signaling in ACE inhibitor-induced cough

2026-01-26 genetic and genomic medicine Title + abstract only
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Early failure of antihypertensive medication treatment affects one in four patients, but the underlying mechanisms are poorly understood. We aimed to identify genetic determinants of antihypertensive treatment failure within the first year. Using longitudinal medication data from >400,000 genotyped antihypertensive medication users across 3 cohorts (FinnGen, the UK Biobank, and the Estonian Biobank), we classified short-term antihypertensive use trajectories as Continue, Switch, or Discontinue....

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