Real-world insights into antiobesity medications in an online patient community: a feasibility study
Kalich, B.; Cruz, M.; Shaw, S.; Cordova, J.; Ke, H.; Mina, M.; Chen, B.; Burton, P.
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Decentralized clinical trials offer a scalable approach to evaluate patient research in real-world settings. The COSMOS-DIGITAL study (NCT06761703) was designed to assess the feasibility of recruiting patients using antiobesity medications from an online patient community and aimed to evaluate participants willingness to consent to and complete fully decentralized surveys and at-home self-blood testing. Three-quarters (n = 151; 75.5%) of participants completed all self-collected capillary blood samples, Patient-Reported Outcomes in Obesity (PROS) surveys, and nausea-related surveys. Over 83% of participants completed the surveys (PROS: n = 167; 83.5%; daily nausea: n = 168; 84.0%), and 93% (n = 142/152) of collected blood samples were sufficient or partially sufficient for testing. Overall, participants were satisfied with the at-home blood collection device. Digitally enabled, fully decentralized studies can capture blood samples and survey responses as well as important aspects of patient treatment experiences, adding value to data collected in randomized controlled trials.
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