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Epigenetics in Abdominal Aortic Aneurysm: Mechanisms and Risk Prediction

2026-01-27 cardiovascular medicine Title + abstract only
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BackgroundEpigenetic mechanism underlying susceptibility to abdominal aortic aneurysm (AAA) remain poorly understood. Identifying causal DNA methylation markers for AAA can elucidate the regulatory processes that drive aneurysm formation and would accelerate translational applications. We leveraged the VA Million Veteran Program (MVP) to identify methylation biomarkers and delineate underlying pathways. MethodsWe first conducted an epigenome-wide association study (EWAS) of incident AAA (1,324 ...

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