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Epithelial Reprogramming and Transition during Pulmonary Bioengineering

Mizoguchi, S.; Lee, V.; Kim, H.; Edelstein, S. E.; Wang, N.; Tomas Gracia, M.; Danelski, C.; Haynes, C.; Rivero, R.; Stitelman, D.; Obata, T.; Greaney, A. M.; Tsuchiya, T.; Kyriakides, T.; Kaminski, N.; Raredon, M. S. B.

2026-01-26 bioengineering
10.64898/2026.01.24.701406 bioRxiv
Show abstract

Recent research has emphasized the critical role of cell state transitions in tissue homeostasis. In lung biology, transitional cells are recognized as a feature of tissue-scale processes during both normal physiology and disease. The precise way that transitional cell states emerge and are regulated remains to be determined. Engineered tissues, built in a laboratory through bioengineering approaches, allow detailed study of cellular states that are not commonly found in native biology, and allow opportunities to directly induce and manipulate cellular transitions. The following study explores and characterizes epithelial cell states that emerge via cellular reprogramming in a tissue engineering context. O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=172 SRC="FIGDIR/small/701406v1_ufig1.gif" ALT="Figure 1"> View larger version (68K): org.highwire.dtl.DTLVardef@1d456f3org.highwire.dtl.DTLVardef@1989ba5org.highwire.dtl.DTLVardef@127dd7org.highwire.dtl.DTLVardef@3dd7a_HPS_FORMAT_FIGEXP M_FIG C_FIG

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