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Is SORL1 a common genetic target across neurodegenerative diseases?: A multi-ancestry biobank scale assessment
2026-01-30
genetic and genomic medicine
Title + abstract only
View on medRxiv
Show abstract
SORL1, the gene encoding the SORLA protein, has arisen as a potential therapeutic target for Alzheimers disease (AD). Studies suggest that restoring SORLA function or its trafficking pathways, particularly the SORLA-retromer recycling system, may offer a promising strategy to slow or halt AD progression. While both rare and common SORL1 variants have been associated with increased AD risk, recent evidence suggests a potential involvement of SORL1 in other neurodegenerative conditions. This study...
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