Global brain activity links subcortical degeneration to cortical tau progressively across Braak regions over early Alzheimer disease stages
Mao, Y.; Pan, B.; Liu, X.
Show abstract
Alzheimers disease (AD) is characterized by early tau pathology in subcortical neuromodulatory nuclei, followed by progressive cortical tau accumulation; however, the mechanisms linking subcortical dysfunction to cortical tau pathology remain unclear. Using multimodal neuroimaging data from the ADNI cohort, we examined how infra-slow (< 0.1 Hz) global brain (i.e., gBOLD) activity is related to the volume of the nucleus basalis of Meynert (NbM) and cortical tau accumulations in the early stages of AD. NbM degeneration was associated with reduced gBOLD activity and spatially co-localized tau accumulation, appearing in early Braak regions during the preclinical stage, i.e., cognitively unimpaired participants with abnormal CSF markers, and extending to more advanced Braak areas during the prodromal stage, i.e., mild cognitive impairment (MCI) subjects. Our findings suggest that infra-slow gBOLD activity serves as a functional neural mediator linking subcortical degeneration to cortical tau pathology, highlighting a potential functional pathway linking subcortical and cortical pathology in early AD.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Amyloid-associated increases in soluble tau is a key driver in accumulation of tau aggregates and cognitive decline in early Alzheimer 98%
- Hemispheric Asymmetry of Tau Pathology is Related to Asymmetric Amyloid Deposition in Alzheimer's Disease 97%
- Plasma p-tau212: antemortem diagnostic performance and prediction of autopsy verification of Alzheimer’s disease neuropathology 96%
Similar papers in this journal
- Default mode network tau predicts future clinical decline in atypical early Alzheimer’s disease 97%
- Selective vulnerability and resilience to Alzheimer's disease tauopathy as a function of genes and the connectome 97%
- Tau-first subtype of Alzheimer's disease consistently identified across in vivo and post mortem studies 97%
Similar papers in this journal
- Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer’s disease 96%
- Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies 95%
- Age, sex and APOE -ε4 modify the balance between soluble and fibrillar β-amyloid in cognitively intact individuals: topographical patterns and replication across two independent cohorts 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.