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Genetic versus Modifiable Risk: Predicting Dementia, Cognition, and Brain Structure in the UK Biobank

2026-01-24 neurology Title + abstract only
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IntroductionBoth genetic and modifiable lifestyle factors contribute to dementia risk, yet their separate and joint predictive value for dementia and its intermediate markers (cognitive function and brain structure), is unclear. This study evaluated APOE {varepsilon}4 status, AD polygenic risk (excluding APOE), and the updated LIBRA2 index (14 modifiable factors) in predicting dementia, cognition, and brain imaging biomarkers. MethodsTo examine associations of APOE {varepsilon}4, PRS-APOE, and ...

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