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Step change in glaucoma polygenic risk score performance enables clinical utility and disease prediction across all major ancestries

2026-01-24 genetic and genomic medicine Title + abstract only
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Glaucoma is the leading cause of irreversible blindness; vision loss is preventable with timely treatment, but early detection is challenging, leaving [~]50% undiagnosed, highlighting the need for improved risk assessment tools. We developed a polygenic risk score (PRS) using data from >6 million individuals. PRS performance was exceptional in European ancestries; top 10% PRS individuals had 10-fold increased risk (OR=10.0) relative to the remainder. Performance remained good across all major an...

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