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DNA Methylation as a Mediator of Cardiovascular Disease Risk in Relation to PTSD Severity: Identification of Potential Epigenetic Biomarkers.
2026-01-23
genetic and genomic medicine
Title + abstract only
View on medRxiv
Show abstract
Post-traumatic stress disorder (PTSD) is associated with increased cardiovascular disease (CVD) risk, yet the epigenetic mechanisms underlying this link remain unclear. We investigated whether DNA methylation (DNAm) within Conserved Regions of Systemic Interindividual Variation (CoRSIVs), genomic regions showing stable within-individual, but variable between-individual methylation, mediates the association between PTSD symptom severity (PTSS) and CVD. We analyzed blood-derived DNAm from three c...
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