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Extracellular Vesicle-Associated Syndecan-1 Differentiates Pediatric Brain Tumor Patients with High-Grade from Low-Grade Pilocytic Astrocytoma

2026-01-27 oncology Title + abstract only
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Reliable non-invasive biomarkers for tumor grading and disease monitoring in pediatric brain tumors are an unmet clinical need. Circulating extracellular vesicles (EVs) carrying molecular cargo reflective of tumor biology, offer promise as liquid biopsy tools. We have previously discovered EV-associated Syndecan-1 (SDC1) to be overexpressed in malignant brain tumors, but its value as a biomarker in pediatric disease remains unclear. In this study, plasma EVs were isolated from pediatric brain tu...

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