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Mitochondria-nucleus communication dictates progressive versus bimodal aging of the mammary gland.

Jenkins, E. C.; Chattopadhyay, M.; Mashaka, T.; Polushakov, D.; Torres-Martin, M.; Sia, D.; Bado, I.; Germain, D.

2026-01-25 cancer biology
10.64898/2026.01.21.700824 bioRxiv
Show abstract

Non-linear aging, identified through oscillations in human plasma proteomics around 44 and 60, is postulated to contribute to the onset of diseases. Incidence of breast cancer follows such bimodal pattern. We show that mitochondria-nucleus matching in mice results in two mammary gland aging patterns, including a bimodal pattern associated with susceptibility to mammary tumor and that this bimodal signature is enriched in breast cancer patients diagnosed at 45 and 65.

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The top 8 journals account for 50% of the predicted probability mass.

1
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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.