Linking interpersonal differences in gut microbiota composition and drug biotransformation activity
Mastrorilli, E.; Herd, P.; Rey, F. E.; Goodman, A.; Zimmermann, M.
Show abstract
Individuals vary widely in their responses to drugs, and growing evidence implicates the gut microbiome as a contributor to this variability. While prior studies show that gut bacteria can metabolize drugs, how differences in microbial community composition influence drug metabolism remains poorly understood. Here, we characterize the biotransformation of 271 drugs by 89 gut microbial communities derived from human donors and preclinical animal models. Over 90% of tested drugs were metabolized by at least one microbiome. We identified 66 drugs exhibiting highly variable metabolism across human-derived microbiomes and several drugs whose biotransformation differed markedly between human and animal microbiomes. To enable prediction of microbiota-mediated drug metabolism, we developed and compared multiple modeling approaches based on metagenomic data. These results, together with the provided data and analytical resources contribute to a better understanding of microbiome-drug interactions and support their future integration into drug discovery, personalized prescription, and therapeutic drug monitoring.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Disease-specific loss of microbial cross-feeding interactions in the human gut 95%
- Biosynthetic Enzyme-guided Disease Correlation Connects Gut Microbial Metabolites Sulfonolipids to Inflammatory Bowel Disease Involving TLR4 Signaling 95%
- Choosing Your Battles: Which Resistance Genes Warrant Global Action? 94%
Similar papers in this journal
- A novel in silico method employs chemical and protein similarity algorithms to accurately identify chemical transformations in the human gut microbiome 94%
- Antimicrobial activity of iron-depriving pyoverdines against human opportunistic pathogens 93%
- Metapopulation ecology links antibiotic resistance, consumption and patient transfers in a network of hospital wards 93%
Similar papers in this journal
- Antibiotic perturbation of the human gut phageome preserves its individuality and promotes blooms of virulent phages. 94%
- Towards a Health-Associated Core Keystone (HACK) index for the human gut microbiome 94%
- Unveiling the Evolution of Antimicrobial Peptides in Gut Microbes via Foundation Model-Powered Framework 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.