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Evaluating ANO6 as a Parkinson's disease candidate gene: a human genetic investigation of common and rare variant associations

2026-01-23 genetic and genomic medicine Title + abstract only
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ANO6 (TMEM16F), a Ca2{square}-activated lipid scramblase and ion channel, has been implicated in -synuclein secretion and propagation, a hallmark of Parkinsons disease (PD). To evaluate whether genetic variation in ANO6 contributes to PD risk, we analyzed common and rare variants across large-scale datasets. Relying on genome-wide association study (GWAS) summary statistics from 63,555 PD cases, 17,700 proxy cases, and 1.7 million controls, we identified seven noncoding common variants within AN...

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