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Physiology-Informed Conditional Variational Autoencoder for Generating Pediatric Virtual Patients
2026-01-24
pharmacology and therapeutics
Title + abstract only
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Reliable pediatric virtual patients are essential for model-informed simulations, including physiologically based pharmacokinetic (PBPK) modeling, to support dose selections in children and to evaluate drug exposure across developmental stages. Despite the availability of extensive pediatric physiological data and age- or size-based models, there remains a lack of well-established, flexible, and scalable approaches for integrating these data into realistic pediatric virtual patients that preserv...
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