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Causal Relationships Between Soluble ST2, Heart Failure, and Sepsis: Bidirectional and Multivariable Mendelian Randomization Analyses

2026-01-22 genetic and genomic medicine Title + abstract only
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BACKGROUNDSoluble ST2 (sST2) predicts poor outcomes in heart failure (HF) and sepsis, but does it actually drive these conditions or just tag along for the ride? We used bidirectional Mendelian randomization (MR) to find out, testing six directional causal pathways among sST2, HF, and sepsis. METHODS AND RESULTSOur approach involved bidirectional two-sample Mendelian Randomization(MR) analyses drawing on genome-wide association study (GWAS) summary statistics: sST2 data came from deCODE Genetic...

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