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Stage-specific gut microbiome shifts across the Type 2 Diabetes Mellitus spectrum: A systematic review and meta-analysis
2026-01-22
endocrinology
Title + abstract only
View on medRxiv
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AimsThe gut microbiome has been implicated in type 2 diabetes progression, but reproducible biomarkers across studies remain limited due to technical and population heterogeneity. This study investigated whether specific gut microbiome shifts occur progressively across stages of type 2 diabetes. MethodsWe systematically reanalysed 16S rRNA datasets from 12 published studies (n=1,247 samples) after quality control, examining five groups (healthy controls, prediabetes (PD), new-onset type 2 diabe...
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