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Gene-exposure interactions regulate cytokine-mediated chronic inflammation and cardiac remodeling

2026-01-22 cardiovascular medicine Title + abstract only
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BackgroundChronic inflammation predicts adverse cardiovascular outcomes, but mechanisms linking systemic inflammation to cardiac remodeling remain incompletely understood. We investigated associations between circulating inflammatory biomarkers and cardiac phenotypes in a population-based cohort and examined how environmental exposures and genetic susceptibility influence inflammatory responses. MethodsWe analyzed subsets of 488,079 UK Biobank participants with metabolomic and proteomic profili...

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