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Brain Region-Specific Oligodendrocyte States Highlight Mitochondrial Gene Upregulation and Loss of Canonical Identity Signatures in Alzheimers Disease

Drummer, F. K.; Jaekel, S.; Dorosti, N.; Hurler, C.; Beltran, E.; Kuemmerle, L. B.; Theis, F. J.

2026-01-14 bioinformatics
10.64898/2026.01.14.699226 bioRxiv
Show abstract

Oligodendrocyte dysfunction and heterogeneity are emerging as key contributors to Alzheimers disease (AD) pathology, though cellular mechanisms remain unclear. Using single-nucleus RNA sequencing across three cortical regions from the same individuals, we identified region- and disease-specific transcriptomic changes, including increased mitochondrial genes and loss of cell type signatures. These results highlight the importance of biologically-informed quality control and underscore the value of multi-regional analysis for understanding AD pathogenesis and progression.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.