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Hypomethylation on cfDNA within transposable elements can predict ovarian malignancy in women with adnexal masses
2026-01-16
oncology
Title + abstract only
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ObjectiveTumor transformation is accompanied by widespread methylation changes, in the form of cytosine modifications, in transposable elements (TEs). The purpose of this study was to investigate whether changes in methylation and hydroxymethylation in the form of 5mC and 5hmC within transposable elements in circulating cell-free DNA (cfDNA) can serve as predictive markers of ovarian malignancy. MethodsHealthy women as well as women undergoing surgery for various benign, borderline, or malignan...
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