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Determinants of the plasma metabolome: cross-sectional and longitudinal associations over 6 years in the NESDA cohort
2026-01-16
epidemiology
Title + abstract only
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The plasma metabolome represents a valuable molecular readout of a persons physiological state, yet its relation to health, stress and lifestyle remains underexplored collectively. Here, we conducted an untargeted metabolomics analysis using 3804 paired samples from 1902 participants of the Netherlands Study of Depression and Anxiety at baseline and 6-year follow-up, quantifying 680 plasma metabolites. We characterised five metabolome profiles using principal component analysis, three with disti...
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