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Statistical Analysis Plan for the Cardiac Magnetic Resonance GUIDEd Management of Mild-moderate Left Ventricular Systolic Dysfunction (CMR GUIDE) trial

2026-01-15 cardiovascular medicine Title + abstract only
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The CMR Guide trial aims to determine whether the insertion of an Implantable Cardioverter Defibrillator based on the presence of ventricular scar/fibrosis will reduce sudden cardiac death or syncopal ventricular arrhythmia in patients with mild moderate left ventricle systolic dysfunction compared to standard care. This statistical analysis plan pre-specifies the method of analysis for every outcome and key variables collected in the trial. The primary outcome is a composite of sudden cardiac ...

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