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Simultaneous quantification of drugs in whole blood by ultra-performance liquid chromatography-tandem mass spectrometry using solid-phase mini-cartridges (Smart-SPE) for sample preparation

2026-01-15 forensic medicine Title + abstract only
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ObjectiveDrug poisoning cases due to overdoses of over-the-counter (OTC) medications are increasing, and comprehensive measurement of blood drug concentrations, including OTC drugs, is important in emergency medicine and forensic science. In this study, we developed a simultaneous quantification method for blood drug levels using LC-MS/MS with solid-phase mini-cartridge SmartSPE for sample preparation. MethodsThe target analytes were acetaminophen, caffeine, flunitrazepam, 7-aminoflunitrazepam,...

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