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Palette polygenic risk score framework improves risk prediction by capturing clinical heterogeneity of type 2 diabetes

2026-01-13 genetic and genomic medicine Title + abstract only
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Polygenic risk scores (PRSs) are typically constructed under the assumption of a single, homogeneous disease phenotype. However, many common diseases exhibit considerable clinical heterogeneity and encompass multiple subtypes with distinct etiologies and clinical characteristics. As a result, conventional PRSs often overlook differences in underlying biological pathways among disease subtypes, consequently limiting predictive accuracy and cross-ancestry transferability. To address this challenge...

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