Glial vesicular transmitter release is not critical for courtship conditioning memory in Drosophila melanogaster
Migues, P. V.; Hardt, O.
Show abstract
Glial cell function is believed to be critical for the regulation of cognitive processes such as learning and memory but the mechanisms by which glia regulate memory are still poorly elucidated. There is evidence that glial metabolic support and neurotransmitter synaptic clearance are essential for memory processes. But glial cells can also influence neuronal activity by the vesicular release of gliotransmitters in a calcium-dependent manner. Whether gliotransmission also is critical for memory process remains controversial. Here, we explored the role of gliotransmission in Drosophila courtship memory using the thermo-sensitive Shibirets mutant in combination with the UAS/Gal4 expression system, in which glial vesicular transmitter release can be rapid and reversibly impaired. We found that the formation, maintenance and decline of courtship memory were unaffected by the blockade of vesicular release of gliotransmitters. Therefore, our data support the view that the release of gliotransmitters is not an ubiquitously necessary regulatory mechanism of memory and forgetting processes.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- A Familial Alzheimers Disease Associated Mutation in Presenilin-1 Mediates Amyloid-Beta Independent Cell Specific Neurodegeneration 94%
- Collective action or individual choice: Spontaneity and individuality contribute to decision-making in Drosophila 94%
- The evolutionarily conserved PhLP3 is essential for sperm development in Drosophila melanogaster 92%
Similar papers in this journal
Similar papers in this journal
- Cold-sensing TRP channels and temperature preference modulate ovarian development in the model organism Drosophila melanogaster 93%
- Mutations in Complex I of the mitochondrial electron-transport chain sensitize the fruit fly (Drosophila melanogaster) to ether and non-ether volatile anesthetics 92%
- Modulation of metabolic hormone signaling via a circadian hormone and a biogenic amine in Drosophila melanogaster. 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.