Mitochondrial hitch-hiking of Mapt mRNA maintains Tau levels in axons
Murali Mahadevan, H.; Rehailia, A. E.; Pastor, A. M.; Geelhaar, I. M. C.; Roman-Albasini, L.; Feederle, R.; Brill, M. S.; Misgeld, T.; Harbauer, A. B.
Show abstract
Hitch-hiking of transcripts on organelles, including mitochondria, has emerged as a common pathway to transport mRNAs into the axon to enable their local translation. However, the extent of mitochondrial mRNA association in vivo has not been established. Here we report the landscape of mitochondrial mRNA association in two nerve tissues, the retinal ganglion cell derived optic nerve and the motor neuron derived part of the sciatic nerve. This revealed astonishing tissue diversity between mitochondria associated mRNAs that can partly be explained by the lack of expression of the mitochondrially anchored RNA-binding protein SYNJ2a in motor neurons. This diversity led us to discover that also MAPT mRNA, encoding the axon-enriched microtubule associated protein Tau, is transported via the mitochondrial RNA anchoring complex SYNJ2a/SYNJ2BP into axons of glutamatergic neurons. Loss of SYNJ2BP prevents axonal localization of MAPT and miss-sorting of Tau, consequently stunting axonal growth in cultured hippocampal neurons. This connects mitochondrial transport to the maintenance of the local cytoskeleton and axonal growth in glutamatergic neurons.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Astroglial exosome HepaCAM signaling and ApoE antagonization coordinates early postnatal cortical pyramidal neuronal axon growth and dendritic spine formation 96%
- The transcriptional response of cortical neurons to concussion reveals divergent fates after injury 95%
- Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration 95%
Similar papers in this journal
Similar papers in this journal
- Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission 96%
- Phosphoglycerate kinase 1 is a central leverage point in Parkinson's disease driven neuronal metabolic deficits 95%
- Neurons burdened by DNA double strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration. 95%
Similar papers in this journal
- MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior 95%
- Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson's disease 94%
- Maintenance of neuronal TDP-43 expression requires axonal lysosome transport 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.