Back
Top 0.2%
18.1%
Top 0.5%
14.9%
Top 0.8%
11.2%
Top 0.5%
9.2%
Top 0.4%
8.0%
Top 43%
6.1%
Top 3%
5.1%
Top 6%
3.1%
Top 89%
3.1%
Top 3%
2.0%
Top 36%
2.0%
Top 2%
1.6%
Top 4%
1.6%
Top 4%
1.6%
Top 9%
1.4%
Top 2%
1.0%
Top 2%
1.0%
Top 7%
0.7%
Top 4%
0.7%
Top 24%
0.5%
ClinAgent: A Five-Layer Architecture for Autonomous Clinical Trial Statistical Programming
2026-01-16
health informatics
Title + abstract only
View on medRxiv
Show abstract
Clinical trial statistical programming requires 12-24 FTE-months for a typical Phase 3 study, producing 100-500 tables, listings, and figures (TLFs) across 8-15 ADaM domains. Modern AI coding agents (Augment Code, Claude Code, Cline, Cursor) demonstrate remarkable reasoning capabilities but lack the domain-specific tools needed for clinical programming: they cannot read SAS datasets, parse ADaM specifications, analyze regulatory-relevant log issues, or generate CDISC-compliant code without exten...
Predicted journal destinations
1
Journal of the American Medical Informatics Association
53 training papers
2
npj Digital Medicine
85 training papers
3
PLOS Digital Health
88 training papers
4
Journal of Biomedical Informatics
37 training papers
5
JAMIA Open
35 training papers
6
Scientific Reports
701 training papers
7
BMC Medical Informatics and Decision Making
36 training papers
8
Journal of Medical Internet Research
81 training papers
9
PLOS ONE
1737 training papers
10
Computers in Biology and Medicine
39 training papers
11
Nature Communications
483 training papers
12
BMC Medical Research Methodology
41 training papers
13
International Journal of Medical Informatics
25 training papers
14
JMIR Medical Informatics
16 training papers
15
PLOS Computational Biology
141 training papers
16
Bioinformatics
24 training papers
17
Patterns
15 training papers
18
Communications Medicine
63 training papers
19
Frontiers in Digital Health
18 training papers
20
Nature Medicine
88 training papers