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Peptidomic profiling reveals extracellular matrix remodeling signatures discriminative of multiple myeloma

2026-01-12 oncology Title + abstract only
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Multiple myeloma (MM) evolves from monoclonal gammopathy of undetermined significance (MGUS) and smoldering MM (SMM) with annual progression rates of 1% and 10%, respectively. Current risk models dont fully capture the underlying dynamic molecular processes. We hypothesized that urinary peptides reflect disease-specific microenvironmental alterations in plasma cell dyscrasias. To test this hypothesis, capillary electrophoresis-mass spectrometry CE-MS was applied to profile the urinary peptidome ...

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