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Prostate cancer risk prediction using polygenic hazard scores in Nordic populations

2026-01-08 oncology Title + abstract only
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Context SummaryO_ST_ABSKey ObjectiveC_ST_ABSCan polygenic hazard scores accurately predict prostate cancer disease risk and age at diagnosis in Nordic populations? Knowledge GeneratedPolygenic hazard score PHS601 stratified prostate cancer risk with a towfold increase per standard deviation increase in two Norwegian populations (N = 17,538). The top 1.7% of scores conferred 8.7-fold higher risk compared with median risk, exceeding the risk associated with pathogenic HOXB13 variants. PURPOSEMor...

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