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Early degeneration of motor pathways in prodromal Parkinsons disease: A fixel-based structural connectivity analysis

2026-01-08 neurology Title + abstract only
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BackgroundIdiopathic REM sleep behavior disorder (iRBD) and hyposmia are the strongest clinical indicators of prodromal Parkinsons disease, reflecting distinct proposed pathways of -synuclein pathology propagation. According to the body-first/brain-first model, iRBD represents a body-first phenotype with early brainstem involvement, whereas hyposmia may reflect a brain-first phenotype with early limbic involvement. We therefore hypothesized that these markers would show distinct fiber-specific w...

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