damidBind: an R/Bioconductor package for differential DamID analysis and data exploration

SummaryDamID, and its cell-type specific adaptations, including Targeted DamID (TaDa), Chromatin Accessibility TaDa (CATaDa) and NanoDam, are now widely-adopted as techniques for the genome-wide profiling of DNA binding proteins. Despite this popularity, no software solution exists for identifying differentially bound or accessible loci or transcribed genes between cell types using DamID. The R/Bioconductor package damid-Bind provides these functions, allowing an end-user to move from raw binding profiles to identifying differentially-bound loci in a reproducible, statistically-robust and straightfor-ward workflow. Availability and ImplementationdamidBind is open-source and freely available from https://bioconductor.org/packages/damidBind/ and https://github.com/marshall-lab/damid-Bind. The package is implemented in R, and is released under the GPLv3 licence. ContactOwen Marshall (owen.marshall@utas.edu.au)