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Single-cell proteome profiling reveals distinct immunological patterns in the lungs of patients with severe acute respiratory failure

2026-01-08 intensive care and critical care medicine Title + abstract only
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In this study, we provide a comprehensive characterization of the alveolar immune landscape in patients suffering from severe acute respiratory failure, predominantly caused by pneumonia or acute respiratory distress syndrome, conditions defined by intense pulmonary inflammation and immune dysregulation. Despite diverse underlying causes, the overall composition of alveolar immune cells was largely consistent, with neutrophils and macrophages comprising the majority of cells. However, the matura...

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