Back

MR-μScope: a multi-scale and simultaneous MRI-miniaturized microscopy system for elucidating neurovascular coupling

Zhu, X.; Li, R.; Li, H.; Gu, L.; Chen, L.; Xu, J.; Chen, J.; Li, Y.; Rudin, M.; Thompson, G. J.; Zhou, N.; Ren, W.

2026-01-06 bioengineering
10.64898/2026.01.05.697821 bioRxiv
Show abstract

Blood Oxygen Level Dependent functional MRI (BOLD-fMRI) revolutionized non-invasive brain mapping, yet the physiological origins of its signal, linking microscopic neurovascular activity to macroscopic hemodynamics, remain elusive. To bridge this gap, we developed MR-Scope: a simultaneous and multimodal platform that integrates preclinic high-field MRI (9.4T) and miniaturized fluorescence microscopy (Miniscope). Our system contains an MR-compatible Miniscope with electromagnetic shielding, a customized radiofrequency coil with a central optical window, and an adjustable animal cradle, enabling artifact-free acquisition of whole-brain fMRI alongside microscopic vascular dynamics. Phantom validation confirmed negligible cross-modal interference (fMRI SNR [≥] 15 dB; optical SNR [≥] 26 dB). MR-Scope captured stimulus-evoked microvascular dilation and blood flow velocity changes in the somatosensory cortex concurrent with BOLD signals, revealing vessel-size-dependent neurovascular coupling. MR-Scope provides an effective solution for deciphering multi-scale neurovascular interactions and offers unique potential for advancing research into brain function and disease mechanisms involving vascular pathology.

Matching journals

The top 7 journals account for 50% of the predicted probability mass.

1
NeuroImage
○ 903 papers in training set
Top 2%
10.4%
Similar papers in this journal
2
Photoacoustics
○ 12 papers in training set
Top 0.1%
9.4%
Similar papers in this journal
3
Journal of Cerebral Blood Flow & Metabolism
○ 42 papers in training set
Top 0.1%
7.7%
Similar papers in this journal
4
Nature Communications
○ 5641 papers in training set
Top 22%
7.7%
Similar papers in this journal
5
Advanced Science
○ 286 papers in training set
Top 0.6%
7.1%
Similar papers in this journal
6
Nature Biomedical Engineering
○ 47 papers in training set
Top 0.3%
4.3%
7
Scientific Reports
○ 3612 papers in training set
Top 23%
4.3%
50% of probability mass above
8
Science Advances
● 1243 papers in training set
Top 9%
3.9%
9
Imaging Neuroscience
● 282 papers in training set
Top 2%
3.9%
10
Magnetic Resonance in Medicine
○ 85 papers in training set
Top 0.3%
3.3%
11
Brain Stimulation
○ 125 papers in training set
Top 0.6%
3.2%
12
IEEE Transactions on Medical Imaging
● 21 papers in training set
Top 0.2%
3.1%
13
Journal of Neural Engineering
○ 221 papers in training set
Top 1%
2.1%
14
eLife
● 5828 papers in training set
Top 52%
1.7%
15
Frontiers in Neuroscience
○ 256 papers in training set
Top 3%
1.7%
16
Communications Biology
○ 993 papers in training set
Top 16%
1.6%
17
Theranostics
● 37 papers in training set
Top 0.5%
1.5%
18
npj Imaging
○ 12 papers in training set
Top 0.1%
1.3%
19
PLOS ONE
● 5266 papers in training set
Top 51%
1.3%
20
Journal of Controlled Release
○ 44 papers in training set
Top 0.5%
1.3%
21
Biomedical Optics Express
● 95 papers in training set
Top 0.8%
1.1%
22
IEEE Transactions on Biomedical Engineering
● 40 papers in training set
Top 0.8%
1.1%
23
Small Methods
○ 29 papers in training set
Top 0.5%
1.1%
24
Biomaterials
○ 84 papers in training set
Top 1%
1.0%
25
Advanced Functional Materials
○ 46 papers in training set
Top 1.0%
1.0%
26
Light: Science & Applications
○ 16 papers in training set
Top 0.3%
0.8%
27
Computers in Biology and Medicine
○ 128 papers in training set
Top 5%
0.8%

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.