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Application of Mendelian randomization to appraise causality in relationships between the gut microbiome and cancer

2026-01-05 epidemiology Title + abstract only
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Cancer is among the leading causes of death worldwide; however, with incidence rising, there is a requirement to identify novel risk factors and biomarkers to prevent and diagnose cancer earlier. Previous work has implicated a role of the gut microbiome in cancer aetiology; however, its causal relevance is not clear. Whilst Mendelian randomisation (MR) is increasingly being applied to assess the causal role of the gut microbiome on several health outcomes, the complexities and limitations of the...

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